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. 2011 Jun 9;7(6):e1002081. doi: 10.1371/journal.ppat.1002081

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(A) Neutralization titers to NJ/76, Mex/4108/09, NCD/20/99 and Bris/59/07 in NJ/76 clinical trial sera collected pre and post NJ/76 vaccination are shown. The geometric mean of titers (GMT) of neutralization in each group is indicated by the short line. P values were calculated by the comparison of pre and post (after) NJ/76 vaccination with paired t test. (B) Correlation between NJ/76 and Mex/4108/09 neutralizing titers in the sera of after NJ/76 vaccination was evaluated with the Spearman test for nonparametric correlation. r: Spearman r; P: two-tailed P value. The dotted lines in both panels A and B represent the neutralization titer of 160, which has been proposed as a correlate of seroprotection in microneutralization assays involving replicating influenza virus [4]. Protective titers based on neutralization of HA-pseudotypes have not been determined.