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. 2011 Jun 9;7(6):e1002081. doi: 10.1371/journal.ppat.1002081

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(A) Bris.HA1-Mex.HA2 pseudotypes were used to map the target of cross-neutralizing antibodies in the samples with cross-neutralization titers to Mex/4108/09, but not to Bris/59/07, in sera from the contemporary cohort of subjects who received seasonal influenza vaccines. (B) Neutralization to NCD/20/99, but not to Mex/4108/09, was mapped to NCD/20/99 HA1 using NCD.HA1-Mex.HA2 pseudotypes and sera from the contemporary cohort of subjects who received seasonal influenza vaccines. The dotted lines in both panels A and B represent the neutralization titer of 160, which has been proposed as a correlate of seroprotection in microneutralization assays involving replicating influenza virus [4]. Protective titers for neutralization of HA-pseudotypes have not been determined. Data are shown as means +/− SD and reflect two or more independent experiments with each sample run in duplicate. Bris: Bris/59/07; Mex: Mex/4108/09; NCD: NCD/20/99.