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. 2001 Mar 13;98(7):3705–3709. doi: 10.1073/pnas.061028398

Figure 2.

Figure 2

Multiple alignments of the sequences of the WAP-, follistatin-, Ig- and Kunitz-type modules of WFIKKN with those of representative members of the given module families. (A) Multiple alignment of WAP modules of the human WFIKKN protein (wfikkn_hu), murine wdnm1 protein (wdnm_mu, AC Q62477), trout ovulatory protein 2 (op2_salfo_1, op2_salfo_2, and op2_salfo_3, AC Q98988), human Kallmann syndrome protein (kalm_hu, AC P23352), chelonianin of Red Sea turtle (ibp_carcr, AC P00993), and human major epididymis-specific protein e4 precursor (ep4_hu_1 and ep4_hu_2, AC Q14508). (B) Multiple alignment of follistatin domains of the human WFIKKN protein (wfikkn_hu), human SPARC protein (sprc_hu, AC P09486), human follistatin (fsa_hu_1, AC P19883), chicken FLIK protein (flik_chick(AC Q9W600), and rat agrin (agri_rat_1, agri_rat_2, agri_rat_4, agri_rat_5, and agri_rat_6, AC P25304). (C) Multiple alignment of Ig domains of the human WFIKKN protein (wfikkn_hu), unc40 of C. elegans (unc40_caeel, AC U70618), robo proteins of C. elegans, Drosophila melanogaster, and human (robo_caeel, AC T42405; robo_drome, AC Q9W213; robo2_hu, AC O43608), human protein tyrosine kinase 7 (ptk7_hu, AC Q13308), human muscle-specific kinase (musk_hu, AC O15146), murine dutt1 protein (dutt1_mu, AC O89026), and human deleted in colorectal carcinoma protein (dcc_hu, AC P43146). (D) Multiple alignment of Kunitz domains of human WFIKKN protein (wfikkn_hu_1, wfikkn_hu_2), human tissue factor pathway inhibitor 2 (tfp2_hu_1, tfp2_hu_2, tfp2_hu_3, AC P48307), chelonianin of Red Sea turtle (ibp_carcr, AC P00993), murine hepatocyte growth factor activator-inhibitor type 2 (hai2_mu_1, hai2_mu_2, AC Q9WU03), bovine pancreatic trypsin inhibitor (bpt1_bo, AC P00974), and human Alzheimer's disease amyloid a4 protein precursor (a4_hu, AC P05067). Residues conserved in more than 50% of the aligned sequences are highlighted in bold.