TABLE 2 .
Incidence of diarrhea in infant rabbits inoculated with V. cholerae V51 strain and its derivativesa
| V51 strain | Incidence (% of rabbits with diarrhea) | No. of rabbits with the following diarrhea score: |
Total no. of rabbits | P valueb | ||
|---|---|---|---|---|---|---|
| Severe | Mild | None | ||||
| WT | 100 | 7 | 0 | 0 | 7 | |
| ΔtcpA mutant | 62.5 | 7 | 3 | 6 | 16 | 0.12 |
| ΔvcsN2 mutant | 53.8 | 3 | 4 | 6 | 13 | 0.05 |
| ΔtcpA vcsN2 mutant | 0 | 0 | 0 | 6 | 6 | 0.006 |
| ΔctxAB mutant | 77.7 | 5 | 2 | 2 | 9 | |
| ΔctxAB tcpA mutant | 70 | 7 | 0 | 3 | 10 | 1.0 |
| ΔctxAB vcsN2 mutant | 16.7 | 2 | 0 | 10 | 12 | 0.01 |
This table shows the incidence of diarrhea (percentage of rabbits infected with the indicated strains exhibiting diarrhea) and the number of infant rabbits with the different diarrhea scores, and statistical analyses of these results are presented. At least two independent experiments were performed for each mutant strain.
For the ΔtcpA, ΔvcsN2, and ΔtcpA vcsN2 mutants, the P value of the incidence for the mutant strain compared to the value for the WT is shown. For the ΔctxAB, ΔctxAB tcpA, and ΔctxAB vcsN2 mutants, the P value of the incidence for the mutant strain compared to the value for the ΔctxAB mutant is shown.