Figure 1.

A model for how N-terminal domains solubilize their linked domains. The blue, gray, and wrinkled spheres represent the folded N- and C-terminal domains, and incompletely folded C-terminal domains, respectively. The red spots on wrinkled spheres indicate the exposed regions involved in the intermolecular interactions. Thick arrows represent the shift from the oligomeric state to the monomeric state (boxed) of proteins driven by the electrostatic repulsions and steric hindrance of folded N-terminal domains. (Reproduced from Reference [49]).