Figure 2.

A schematic illustration of substrate-stabilizing factors of macromolecules and their correlation with the size of the macromolecule. Here, an example of a soluble macromolecule, DnaK, with varying radius r and constant surface charge density and its bound aggregation-prone protein are represented as sphere A and B, respectively. The potential factors of sphere A such as electrostatic repulsions, steric hindrance, and hydrophobic shielding are considered as a function of the radius r of sphere A. The hatched area represents the surfaces inaccessible to other B by the steric masking of the corresponding A. (Adapted from Reference [58]).