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. 2011 Mar 23;12(3):2077–2087. doi: 10.3390/ijms12032077

Table 1.

Reactivation ability of five oximes to reactivate OP-inhibited human erythrocyte AChE, at concentrations 10−4 M and 10−5 M (%, mean value of three independent determinations; time of reactivation 10 min; pH 7.4; temperature 25 °C).

AChE Paraoxon [17] Dichlorvos DFP [18] Leptophos-oxon [19] Methamidophos

100 μM 10 μM 100 μM 10 μM 100 μM 10 μM 100 μM 10 μM 100 μM 10 μM

Mean SD Mean SD Mean SD Mean SD Mean SD Mean SD Mean SD Mean SD Mean SD Mean SD
Methoxime 23.4 4.5 4.3 1.5 0 0 0.2 0.6 6.4 0.5 1.5 0.5 52.6 0.5 11.9 0.9 61.7 2.4 68.1 11.4
Pralidoxime 18.1 0.9 1.3 0.9 2.6 0.6 0.2 0.6 2.3 0.2 0 0 13.2 0.9 4.1 1.3 53.4 3.1 53.8 22.6
Obidoxime 96.8 0.9 59.4 0.9 0 0 0.6 0.1 17.1 0.1 7.4 0.5 50.3 0.9 31.4 0.2 5.8 4.8 57.0 18.7
Trimedoxime 86.0 1.6 45.3 0.8 0 0 0 0 23.8 0.2 6.4 0.2 51.3 0.5 26.4 2.7 9.4 7.5 53.1 10.9
HI-6 16.1 0.2 3.9 0.9 0 0 0.6 1.1 0 0 0 0 32.8 8.0 11.6 0.4 37.4 12.3 75.2 14.6