Table 1.
Cardiovascular parameters and lipid values of experimental groups
| Systolic blood pressure (mmHg) | Heart rate (bpm) | Total cholesterol (mg·L−1) | LDL cholesterol (mg·L−1) | HDL cholesterol (mg·L−1) | Triglycerides (mg·L−1) | |
|---|---|---|---|---|---|---|
| WT | 111.7 ± 2.5 | 640.8 ± 9.9+ | 21.2 ± 1.9 | 5.3 ± 1.7 | 14.6 ± 2.7 | 7.9 ± 0.8 |
| ApoE−/− | 105.6 ± 2.3 | 593.4 ± 10.9 | 117.8 ± 17.1** | 90.6 ± 14.1** | 26.0 ± 4.2 | 10.8 ± 3.1 |
| ApoE−/−+ ramipril (2.5 mg·kg−1·day−1) | 91.1 ± 2.5**,++ | 635.8 ± 6.2+ | 114.6 ± 18.3** | 85.2 ± 14.8** | 32.6 ± 4.7 | 13.2 ± 3.3 |
| ApoE−/−+ telmisartan (20 mg·kg−1·day−1) | 79.8 ± 3.3**,++,# | 621.2 ± 4.3+ | 121.3 ± 14.6** | 90.7 ± 12.4** | 28.5 ± 5.0 | 11.6 ± 2.5 |
| ApoE−/−+ telmisartan/ramipril (20 mg·kg−1·day−1; 2.5 mg·kg−1·day−1) | 79.7 ± 2.7**,++,# | 639.1 ± 10.2+ | 80.3 ± 16.2* | 68.8 ± 11.3* | 21.5 ± 9.4 | 12.2 ± 3.2 |
Systolic blood pressure and heart rate were determined in all animals. Lipid levels were measured in five to nine mice per group. Data shown are means ± SEM.
*
P < 0.05 versus WT
**
P < 0.001 versus WT
++
P < 0.001 versus ApoE−/−
+
P < 0.05 versus ApoE−/−
#
P < 0.05 versus ApoE−/−+ ramipril.
ApoE−/−, apolipoprotein-E-deficient; HDL, high density lipoprotein; LDL, low density lipoprotein; WT, wild-type.