Table 3.
Parameters (pD2, maximum effect) of endothelium-dependent or -independent relaxations in aortic rings and corpora cavernosal strips
| Wild-type | ApoE−/− | ApoE−/−+ ramipril | ApoE−/−+ telmisartan | ApoE−/−+telmisartan/ramipril | |
|---|---|---|---|---|---|
| Aortic tissue, response to carbachol | |||||
| pD2 (-log) | −5.85 ± 0.22* | −4.71 ± 0.20 | −6.27 ± 0.34* | −5.47 ± 0.18* | −5.70 ± 0.31* |
| Maximum relaxation (%) | 76.4 ± 4.9* | 49.3 ± 5.4 | 81.2 ± 7.7* | 75.7 ± 7.7* | 69.5 ± 4.1* |
| Cavernosal tissue, response to carbachol | |||||
| pD2 (-log) | −7.45 ± 0.07* | −7.16 ± 0.18 | −7.54 ± 0.11* | −7.58 ± 0.08* | −7.66 ± 0.08* |
| Maximum relaxation (%) | 105.3 ± 9.5* | 64.5 ± 4.5 | 95.3 ± 5.6* | 97.2 ± 11.6* | 109.2 ± 13.3* |
| Aortic tissue, response to glyceryl trinitrate | |||||
| pD2 (-log) | −6.22 ± 0.08 | −6.36 ± 0.12 | −6.40 ± 0.20 | −6.69 ± 0.09 | −6.72 ± 0.15 |
| Maximum relaxation (%) | 124.3 ± 11.8 | 141.9 ± 9.1 | 142.9 ± 11.4 | 108.2 ± 6.1 | 113.5 ± 7.1 |
| Cavernosal tissue, response to glyceryl trinitrate | |||||
| pD2 (-log) | −5.56 ± 0.14 | −5.69 ± 0.13 | −5.54 ± 0.20 | −5.57 ± 0.13 | −5.73 ± 0.19 |
| Maximum relaxation (%) | 46.4 ± 6.5 | 57.3 ± 6.9 | 43.5 ± 3.3 | 46.6 ± 5.9 | 53.6 ± 7.4 |
Endothelium-dependent relaxations were induced by carbachol and endothelium-independent relaxations by glyceryl trinitrate. Data shown are means ± SEM from six to ten mice per group.
*
P < 0.05 versus ApoE−/− mice.
ApoE−/−, apolipoprotein-E-deficient.