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. 2011 Jun;163(4):857–875. doi: 10.1111/j.1476-5381.2011.01287.x

Figure 7.

Figure 7

Effects of protein kinase C and ERK kinase (MEK) blockade on body weight loss after naloxone-induced morphine withdrawal. Rats were implanted with morphine or placebo pellets for 7 days and pretreated with vehicle, calphostin C, chelerythrine or SL-327. Weight loss was checked immediately before and 60 min after naloxone injection. Data shown are means ± SEM. Post hoc tests revealed that calphostin C significantly attenuated the increase in body weight loss that was seen during morphine withdrawal. (A) ***P < 0.001 versus placebo + naloxone; +++P < 0.001 versus morphine + saline. (B,C) ***P < 0.001 versus placebo + vehicle + naloxone; +P < 0.05, +++P < 0.001 versus morphine + vehicle + naloxone. (D) +++P < 0.001 versus morphine + dimethyl sulphoxide (DMSO) + naloxone. (B–D) ###P < 0.001 versus placebo + calphostin + naloxone, placebo + chelerythrine + naloxone or placebo + SL-327 + naloxone respectively. chel, chelerythrine; cp, calphostin C; m, morphine pellets; n, naloxone; p, placebo pellets; veh, vehicle.