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. 2001 Mar 27;98(7):3710–3715. doi: 10.1073/pnas.061455898

Figure 1.

Figure 1

Multiple sequence alignment between human CRBP III and previously characterized CRBPs. Residues that are identical or similar in at least five of the six sequences are boxed in black or gray, respectively. The symbols below amino acid letter residues denote: ○, residues that in rat retinol–CRBP I change their accessible surface area by more than 1 Å2 after ligand removal (4); +, residues that have an atom within a distance of 3.6–5.1 Å from bound retinol in rat retinol–CRBP II (5); ×, residues that have an atom within 3.6 Å of bound retinol in rat retinol–CRBP II (5). The positions of β-strands A-J (arrows) and α-helices A and B (boxes) are indicated according to ref. 4. Conservative substitutions are defined as follows: A/I/L/M/V, S/T, F/Y/W, D/E, N/Q, and K/R. GenBank accession nos. are: P09455 and P50120, human (h) CRBP I and II, respectively; P02696 and P06768, rat (r) CRBP I and II, respectively; CA885608, gecko (g) (Lygodactylus picturatus) ι-crystallin/CRBP.