Table 1.
Results of endoscopic transsphenoidal pituitary surgery in patients with acromegaly (1998–2007)
| Patient number, gender, age (years) | Preoperative octreo-tide | MRI (mm) | Invasion on preoperative MRI | Year of TS | Postoperative IGF-1 | Postoperative oGTT | TS result | Additional therapy | Last IGF-1 | Follow-up (months) | ||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| nmol/l | SD | nmol/l | SD | |||||||||
| 1. f, 52 | Y | 20 | Sc r | 1998 | 50.3 | >2 | - | F | RT + cab | 19.0 | 1 | 127 |
| 2. m, 43 | N | 25 | - | 1999 | 24.0 | 1 | 38 | F | Octr | 32.8 | >2 | 38 |
| 3. f, 27 | N | 18 | Sc r | 2000 | 92.7 | >2 | 9 | F | GK | 10.6 | -2 | 109 |
| 4. m, 40 | Y | 10 | - | 2000 | 23.1 | 1 | <2 | R | - | 12.9 | -1 | 106 |
| 5. f, 24 | Y | 17 | - | 2000 | 77.0 | >2 | - | F | Octr + cab | 41.0 | >2 | 78 |
| 6. f, 59 | Y | 20 | Ssphen,sc l | 2001 | 64.5 | >2 | - | F | TS, RT + peg | 15.6 | 0 | 76 |
| 7. f, 54 | N | 11 | Sc l | 2001 | 62.8 | >2 | - | F | RT + octr | 23.5 | 1 | 73 |
| 8. m, 39 | N | 14 | - | 2001 | 73.6 | >2 | - | F | RT + octr, cab | 28.1 | 2 | 68 |
| 9. m, 49 | Y | 43 | Ssphen, sc l + r | 2001 | 60.5 | >2 | - | F | TS + octr, cab | 21.6 | 1 | 91 |
| 10. f, 50 | Y | 12 | - | 2001 | 10.2 | -2 | <2 | R | - | 15.4 | 0 | 74 |
| 11. f, 49 | Y | 13 | - | 2001 | 38.4 | >2 | - | F | Octr | 14.0 | 0 | 91 |
| 12. m, 37 | Y | 20 | - | 2001 | 28.3 | 1 | <2 | R | Octr | 15.6 | 0 | 87a |
| 13. m, 44 | Y | 10 | Sc r | 2001 | 83.6 | >2 | - | F | GK + octr, peg | 27.9 | 2 | 86 |
| 14. f, 34 | Y | 16 | - | 2002 | 10.5 | -2 | <2 | R | - | 11.4 | -2 | 70 |
| 15. f, 55 | Y | 18 | - | 2002 | 30.9 | >2 | 3 | F | Octr | 9.8 | -2 | 86 |
| 16. f, 56 | Y | 11 | Sc r | 2002 | 12.7 | -1 | <2 | R | - | 13.6 | 0 | 79 |
| 17. m, 56 | Y | 14 | - | 2002 | 16.8 | 0 | <2 | R | - | 15.2 | 0 | 77 |
| 18. m, 64 | Y | 12 | - | 2002 | 18.0 | 1 | 2 | F | Octr | 18.3 | 1 | 57 |
| 19. f, 66 | Y | 16 | Ssphen, sc r | 2003 | 27.1 | 2 | <2 | R | - | 25.0 | 2 | 65 |
| 20. f, 45 | Y | 30 | Sc l | 2003 | 24.7 | 1 | <2 | R | - | 29.0 | 2 | 48 |
| 21. m, 35 | Y | 39 | Ssphen | 2003 | 66.3 | >2 | - | F | Octr | 14.1 | -1 | 69 |
| 22. f, 56 | Y | 15 | Sc r | 2003 | 15.3 | 0 | <2 | R | - | 16.5 | 0 | 47 |
| 23. f, 41 | Y | 15 | - | 2003 | 28.0 | 1 | <2 | R | - | 22.7 | 1 | 66 |
| 24. m, 54 | Y | 13 | - | 2004 | 19.8 | 1 | <2 | R | - | 16.6 | 0 | 44 |
| 25. f, 43 | Y | 11 | - | 2004 | 29.5 | 2 | <2 | R | - | 22.8 | 1 | 43 |
| 26. m, 48 | N | 12 | - | 2005 | 35.8 | >2 | - | F | Octr | 23.6 | 1 | 31 |
| 27. f, 29 | Y | 10 | Sc l | 2005 | 25.6 | 1 | <2 | R | - | 23.5 | 1 | 37 |
| 28. f, 51 | Y | 13 | - | 2005 | 11.7 | -1 | <2 | R | - | 15.6 | 0 | 49 |
| 29. m, 64 | Y | 14 | Sc r | 2005 | 30.0 | >2 | - | F | Cab | 21.4 | 1 | 36 |
| 30. m, 68 | Y | 30 | Sc l + r, ssphen | 2005 | 31.5 | >2 | - | F | Octr | 16.8 | 1 | 30 |
| 31. m, 46 | Y | 21 | - | 2005 | 43.1 | >2 | <2 | F | - | 36.2 | >2 | 32 |
| 32. m, 45 | N | 15 | - | 2005 | 46.0 | >2 | <2 | F | - | 31.3 | >2 | 38 |
| 33. m, 35 | Y | 42 | Sc l + r | 2005 | 163.8 | >2 | 595 | F | RT + octr, cab | 56.9 | >2 | 33 |
| 34. f, 28 | Y | 45 | Sc l + r | 2006 | 98.7 | >2 | - | F | RT + octr | 33.3 | >2 | 15 |
| 35. f, 67 | Y | 11 | - | 2006 | 21.5 | 1 | <2 | R | - | 27.4 | >2 | 31a |
| 36. m, 40 | Y | 21 | Sc r | 2007 | 22.9 | 0 | <2 | R | - | 21.3 | 1 | 14 |
| 37. m, 62 | Y | 20 | - | 2007 | 18.4 | 1 | <2 | R | - | 18.4 | 1 | 6 |
| 38. f, 41 | Y | 24 | Sc re | 2007 | 31.7 | 2 | <2 | R | - | 12.0 | -1 | 15 |
| 39. f, 46 | Y | 18 | - | 2007 | 16.2 | 0 | <2 | R | - | 21.3 | 1 | 8 |
| 40. m, 54 | Y | 27 | Sc r | 2007 | 26.6 | 2 | <2 | R | - | 26.6 | 2 | 6 |
f: female; m: male; preoperative octreotide Y: treated with octreotide before surgery; preoperative octreotide N: not treated with octreotide before surgery; MRI: magnetic resonance imaging results given as maximal diameter of the visualised tumour in mm; sc r: cavernous sinus right; sc l: cavernous sinus left; ssphen: shenoid sinus; ssphen: sphenoid sinus; TS: transsphenoidal surgery; IGF-1 nmol/l: value of insulin-like growth factor-1; IGF-1 SD: standard deviation of insulin-like growth factor-1 compared to normal values in people of the same age and sex; oGTT: minimal value of growth hormone achieved during the postoperative oral glucose tolerance test; GTT -: no oral glucose tolerance test performed after surgery; TS result R: remission; TS result F: failure; RT: conventional radiotherapy; octr: octreotide; cab: cabergoline; GK: gamma knife radiosurgery; peg: pegvisomant; a: relapse at last follow-up