TABLE 1.

Assignment of genes, metabolites, and physiological parameters to biological processes

Biological Cluster	Endocannabinoid Signaling	Lipid Transport	Lipogenesis	Energy Expenditure	Energy Intake	Glucose Metabolism
Genes	Adipose tissues CB1, upper intestine CB1 and GPR119, upper intestine and adipose tissues FAAH and NAAA, upper intestine OEAs	Adipose tissues, liver and upper intestine CD36, liver PCSK9, upper intestine and adipose tissues FIAF	Liver FAS, SREBP1c, SREBP2, liver and adipose tissues SCD1, adipose tissue SREBP1c, and SREBP2	Liver ACO, adipose tissue epid. Adiponectin, liver, upper intestine and adipose tissues CPT1, muscle UCP2, upper intestine PPAR-α	Upper intestine CCK, stomach leptin and ghrelin, adipose tissues leptin	Muscle GLUT4, liver G6P and     PEPCK, adipose tissues visfatin
Metabolites		Plasma cholesterol, plasma FFA, HDL-C, non-HDL-C, plasma TG	Liver TG, liver FA and glycerol	Plasma β-hydroxybutyrate		Plasma glucose
Physiological parameters	FAAH activity in intestine		Plasma insulin	Adiponectin, indirect calorimetry LOX, GOX, RQ, and EE, spontaneous activity	Plasma ghrelin, plasma leptin, cumulative food intake	Plasma insulin

RQ, respiratory quotient; TG, triglyceride. Biological variables in boldface type indicate those variables modified by treatments (with 95% confidence interval, as determined from the PLS analysis) and used to calculate the biological module scores (hierarchical PLS).