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. Author manuscript; available in PMC: 2012 Jul 1.
Published in final edited form as: Neurobiol Learn Mem. 2011 Feb 19;96(1):79–88. doi: 10.1016/j.nlm.2011.02.008

Figure 6. Dendritic atrophy and enduring upregulation of CRH expression in hippocampus of middle-aged rats experiencing chronic early-life stress.

Figure 6

Left Panel: Atrophy of the apical dendritic trees of CA1 pyramidal cells accompanied loss of spatial memory and attenuated LTP in 12 month old rats that experienced one week of chronic stress during postnatal days 2–9. The image depicts representative neurons filled with biocytin (From Brunson et al., 2005, with permission). Right panel: Increased number of immunocytochemistry-detectable CRH-expressing interneurons in hippocampi of middle-aged rats that experienced early-life stress (highlighted by arrows). All sections were run together, and cells were quantified in the pyramidal cells layers of areas CA3 and CA1 (from Ivy et al., 2010, with permission).