Table 4.

Reports of perioperative blood loss after TKA without tranexamic acid prophylaxis

Study	Study design	Number of patients	VTE chemoprophylaxis	Method of blood loss calculation	Perioperative blood loss	Conventional or MIS TKA
Lotke et al. [20] (1991)	Nonblinded RCT	121	Aspirin	Formula by maximum Hb decrease	1518 mL	Conventional
Hiippala et al. [13] (1995)	Double-blinded RCT	29	Enoxaparin	Intraoperative blood loss and postoperative drainage	1549 mL	Conventional
Benoni and Fredin [5] (1996)	Double-blinded RCT	86	Enoxaparin	Intraoperative blood loss and postoperative drainage	1410 mL	Conventional
Keating et al. [17] (1998)	Retrospective study	280	Heparin sodium	Formula by maximum Hb decrease	1925 mL	Conventional
Good et al. [11] (2003)	Double-blinded RCT	51	Dalteparin	Formula by maximum Hb decrease	1426 mL	Conventional
Sehat et al. [31] (2004)	Prospective study	101	None	Formula by maximum Hb decrease	1498 mL	Conventional
Kalairajah et al. [16] (2005)	RCT	60	Aspirin	Formula by maximum Hb decrease	1747 mL	Conventional
Camarasa et al. [9] (2006)	Double-blinded RCT	127	Dalteparin	Formula by maximum Hb decrease	1784 mL	Conventional
Current study	Prospective comparative study	50	Enoxaparin	Formula by maximum Hb decrease	1453 mL	MIS

VTE = venous thromboembolic event; RCT = randomized control trial; TKA = total knee arthroplasty; MIS = minimally invasive surgery; Hb = hemoglobin.