Table 4.

Characteristics and Management of Oral Lesions.

	Verrucous hyperplasia	Dysplasia	Invasive carcinoma
N	3	5	18
Time to Development in years, median (range)†	3 (1, 13)	2 (1, 3)	8 (1, 14)
Cancer Stage
Stage I (T1N0M0)	-	-	7 (39)
Stage II	-	-	6 (33)
T2N0M0			5 (28)
T2N1M0	-	-	1 (6)
Stage III	-	-	4 (22)
T3N0M0	-	-	2 (11)
T3N0MX	-	-	2 (11)
Stage IVa (T4N0M0)	-	-	1 (6)
Focal versus Multifocal
Focal	2 (67)	5 (100)	13 (72)
Multifocal	1 (33)	0 (0)	5 (28)
Location††
Tongue	0 (0)	1 (20)	10 (55)
Lower Lip†††	0 (0)	4 (80)	3 (17)
Buccal mucosa	1 (33)	0 (0)	7 (39)
Gingiva	2 (66)	0 (0)	4 (22)
Hard Palate	1 (33)	0 (0)	1 (5)
Alveolar mucosa	0 (0)	0 (0)	2 (10)
Color
Red	0 (0)	0 (0)	1 (6)
Red/White	0 (0)	2 (40)	8 (44)
White	3 (100)	3 (60)	9 (50)
Clinical appearance††††
Plaque	3 (100)	2 (40)	9 (50)
Exophytic	0 (0)	0 (0)	7 (39)
Ulceration	0 (0)	2 (40)	5 (28)
Papillary	0 (0)	2 (40)	2 (11)
Crusting	0 (0)	2 (40)	1 (6)
Erythema	0 (0)	0 (0)	3 (17)
Pain	0 (0)	1 (20)	11 (61)
Anesthesia/Paresthesia	0 (0)	0 (0)	2 (11)
Management
Surgery alone	3 (100)	4 (80)	12 (67)
Surgery/Radiotherapy	0 (0)	0 (0)	1 (6)
Surgery/topical 5FU	0 (0)	1 (20)	0 (0)
Surgery/Chemotherapy/Radiotherapy	0 (0)	0 (0)	4 (22)
Chemotherapy/Radiotherapy	0 (0)	0 (0)	1 (6)

^†Measured from the date of the 1^st allogeneic transplant to the date of development of initial SCC. The overall median was 5 years (range 1-14).

^††There may have been multiple sites involved per patient, so the frequencies do not sum to N=26 and the percentages do not sum to 100%.

^†††All lesions appeared to originate on the lip; 3 out of 7 cases also extended to the labial mucosa intraorally.

^††††There may have been multiple clinical features per patient, so the frequencies do not sum to N=25 and the percentages do not sum to 100%.