Table 2.
Smoking Status |
|||||
---|---|---|---|---|---|
Never | Past | Current, <15 cigs/day |
Current, ≥15 cigs/day |
P trend* | |
Participants | 20336 | 14263 | 1967 | 3259 | |
Events / Person-years of follow-up | 30 / 260855 | 63 / 182532 | 22 / 24440 | 63 / 39502 | - |
Age-adjusted incidence rate† | 0.12 | 0.34 | 0.95 | 1.63 | - |
Baseline examination | |||||
Age adjusted model (n=39825) | 1.0 (Referent) | 2.95 (1.91–4.55) | 8.76 (5.05–15.21) | 16.51 (10.66–25.57) | <0.001 |
Multivariable model 1 (n=39803)‡ | 1.0 (Referent) | 2.96 (1.92–4.58) | 9.26 (5.33–16.09) | 16.53 (10.66–25.62) | <0.001 |
Multivariable model 2 (n=38960) § | 1.0 (Referent) | 3.14 (2.01–4.90) | 8.93 (5.02–15.89) | 16.95 (10.77–26.67) | <0.001 |
Smoking updated during follow-up | |||||
Age adjusted model (n=39825) | 1.0 (Referent) | 2.97 (1.94–4.55) | 11.28 (6.62–19.21) | 20.99 (13.29–33.15) | <0.001 |
Multivariable model 1 (n=39803) ‡ | 1.0 (Referent) | 2.98 (1.95–4.56) | 11.89 (6.97–20.28) | 21.19 (13.40–33.50) | <0.001 |
Multivariable model 2 (n=38960) § | 1.0 (Referent) | 3.16 (2.04–4.89) | 11.94 (6.90–20.65) | 21.08 (13.10–33.91) | <0.001 |
Subcohort with available blood samples (n=28314) | |||||
Participants | 14631 | 10389 | 1255 | 2039 | |
Events / Person-years of follow-up | 21 / 188625 | 43 / 133470 | 14 / 15742 | 39 / 24878 | - |
Age-adjusted incidence rate† | 0.11 | 0.32 | 1.02 | 1.57 | - |
Age adjusted model (n=28314) | 1.0 (Referent) | 2.85 (1.69–4.80) | 8.98 (4.56–17.68) | 16.45 (9.65–28.05) | <0.001 |
Multivariable model 1 (n=27347) ║ | 1.0 (Referent) | 2.89 (1.70–4.91) | 7.12 (3.46–14.63) | 13.46 (7.38–23.42) | <0.001 |
Multivariable model 2 (n=27159) ¶ | 1.0 (Referent) | 2.83 (1.64–4.86) | 5.58 (2.61–11.93) | 9.52 (5.17–17.53) | <0.001 |
Data are HR (95% CI)
P for trend across categories of cigarette smoking
Incidence rates are per 1000 person years of observation
Additionally adjusted for history of hypertension, history of diabetes, and history of hypercholesterolemia
Additionally adjusted for body mass index, alcohol consumption, and physical activity
Additionally adjusted for history of hypertension, history of diabetes, body mass index, alcohol consumption, physical activity and measured total and high-density lipoprotein cholesterol
Additionally adjusted for high sensitivity C-reactive protein and soluble intercellular adhesion molecule 1
PAD = Peripheral artery disease