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Two alternative structures of thiamine pyrophosphate (TPP) riboswitch in Bacillus subtilis (B. subtilis). (a) Full-length riboswitch when TPP present. Thi-box and terminator are formed (lowest energy structure predicted by mfold). (b) TPP riboswitch when TPP is absent. Anti-terminator is paired with terminator (lowest energy structure with the constraint that prohibits base pairing in terminator stem-loop in (a)).
