Table 3.
Allelic distribution of GCKR polymorphisms and association with type 2 diabetes
| Alleles | Non-DM (%) | DM (%) | Odds Ratio1a | 95% CI | P value | Odds Ratio2b | 95% CI | P value |
|---|---|---|---|---|---|---|---|---|
| rs8179206 | ||||||||
| A | 97.0 | 96.6 | 1 | (Ref.) | 1 | (Ref.) | ||
| G | 3.0 | 3.4 | 1.18 | 0.85-1.65 | 0.32 | 1.29 | 0.91-1.82 | 0.15 |
| rs2293572 | ||||||||
| G | 85.9 | 85.6 | 1 | (Ref.) | 1 | (Ref.) | ||
| C | 14.1 | 14.4 | 1.04 | 0.88-1.23 | 0.64 | 1.04 | 0.88-1.24 | 0.64 |
| rs3817588 | ||||||||
| A | 72.1 | 68.0 | 1 | (Ref.) | 1 | (Ref.) | ||
| G | 27.9 | 32.0 | 1.21 | 1.06-1.39 | 0.004* | 1.24 | 1.08-1.43 | 0.002* |
| rs780094 | ||||||||
| A | 56.6 | 52.6 | 1 | (Ref.) | 1 | (Ref.) | ||
| G | 43.4 | 47.4 | 1.19 | 1.05-1.34 | 0.005* | 1.22 | 1.07-1.38 | 0.002* |
a Adjusted for year of birth and sex
b Adjusted for year of birth, sex and BMI
*Significant after Bonferroni correction (p < 0.0125 (0.05/4) was the corrected statistically significant level in association analysis between the individual SNP and type 2 diabetes)
The major allele was used as a reference when comparing the risk of diabetes between alleles.