Table 4.
Quantitative traits stratified according to GCKR genotypes in non-diabetic controls
| n | BMI (kg/m2) | Waist circumference (cm) | Fasting glucose (mmol/l) | Total cholesterol* (mmol/l) | Triglyceride* (mmol/l) | HDL-C* (mmol/l) | LDL-C* (mmol/l) | Systolic BP (mmHg) | Diastolic BP (mmHg) | |
|---|---|---|---|---|---|---|---|---|---|---|
| rs8179206 | ||||||||||
| AA | 1076 | 23.50 ± 0.09 | 80.50 ± 0.29 | 4.86 ± 0.01 | 5.11 ± 0.03 | 1.45 ± 0.02 | 1.32 ± 0.01 | 3.01 ± 0.03 | 119.14 ± 0.46 | 77.95 ± 0.27 |
| AG | 68 | 23.33 ± 0.39 | 81.48 ± 1.23 | 4.86 ± 0.05 | 5.04 ± 0.11 | 1.52 ± 0.09 | 1.30 ± 0.03 | 2.95 ± 0.10 | 122.28 ± 1.99 | 79.55 ± 1.11 |
| GG$ | 2 | 19.47 ± / | 68.00 ± / | 4.10 ± / | 3.80 ± / | 0.90 ± / | 1.16 ± / | 2.23 ± / | 110.00 ± / | 70.00 ± / |
| P valuea# | 0.36 | 0.33 | 0.19 | 0.27 | 0.51 | 0.61 | 0.53 | 0.45 | 0.76 | |
| P valueb# | 0.15 | 0.31 | 0.49 | 0.24 | 0.64 | 0.35 | 0.72 | |||
| rs2293572 | ||||||||||
| GG | 842 | 23.53 ± 0.10 | 80.60 ± 0.32 | 4.85 ± 0.01 | 5.09 ± 0.03 | 1.44 ± 0.02 | 1.32 ± 0.01 | 3.00 ± 0.03 | 119.32 ± 0.53 | 78.13 ± 0.31 |
| GC | 276 | 23.37 ± 0.17 | 80.22 ± 0.58 | 4.87 ± 0.02 | 5.16 ± 0.06 | 1.51 ± 0.04 | 1.31 ± 0.02 | 3.03 ± 0.05 | 118.96 ± 0.90 | 77.54 ± 0.50 |
| CC | 23 | 24.03 ± 0.53 | 80.00 ± 1.85 | 4.98 ± 0.06 | 5.39 ± 0.19 | 1.53 ± 0.15 | 1.39 ± 0.06 | 3.12 ± 0.17 | 121.24 ± 1.95 | 78.96 ± 1.29 |
| P valuea# | 0.48 | 0.63 | 0.18 | 0.17 | 0.28 | 0.54 | 0.74 | 0.14 | 0.24 | |
| P valueb# | 0.14 | 0.17 | 0.15 | 0.37 | 0.73 | 0.19 | 0.44 | |||
| rs3817588 | ||||||||||
| AA | 598 | 23.35 ± 0.12 | 79.88 ± 0.40 | 4.85 ± 0.02 | 5.13 ± 0.04 | 1.50 ± 0.03 | 1.32 ± 0.01 | 3.02 ± 0.04 | 119.27 ± 0.66 | 77.79 ± 0.38 |
| AG | 423 | 23.52 ± 0.15 | 81.14 ± 0.47 | 4.87 ± 0.02 | 5.08 ± 0.05 | 1.41 ± 0.03 | 1.33 ± 0.02 | 3.00 ± 0.04 | 118.93 ± 0.76 | 78.12 ± 0.45 |
| GG | 103 | 23.97 ± 0.30 | 82.13 ± 1.01 | 4.84 ± 0.04 | 4.99 ± 0.10 | 1.26 ± 0.05 | 1.32 ± 0.03 | 2.95 ± 0.08 | 119.58 ± 1.68 | 77.77 ± 0.94 |
| P valuea# | 0.15 | 0.04 | 0.84 | 0.35 | 0.001& | 0.78 | 0.82 | 0.59 | 0.76 | |
| P valueb# | 0.81 | 0.29 | 0.00004& | 0.70 | 0.84 | 0.39 | 0.63 | |||
| rs780094 | ||||||||||
| AA | 368 | 23.22 ± 0.16 | 79.66 ± 0.50 | 4.84 ± 0.02 | 5.12 ± 0.05 | 1.49 ± 0.04 | 1.32 ± 0.02 | 3.02 ± 0.05 | 119.13 ± 0.87 | 77.83 ± 0.50 |
| AG | 558 | 23.59 ± 0.13 | 80.80 ± 0.42 | 4.86 ± 0.02 | 5.13 ± 0.04 | 1.44 ± 0.03 | 1.32 ± 0.01 | 3.02 ± 0.04 | 119.73 ± 0.70 | 78.40 ± 0.39 |
| GG | 218 | 23.67 ± 0.20 | 81.34 ± 0.70 | 4.85 ± 0.03 | 5.00 ± 0.07 | 1.35 ± 0.04 | 1.32 ± 0.02 | 2.92 ± 0.06 | 119.15 ± 1.04 | 77.33 ± 0.62 |
| P valuea# | 0.15 | 0.16 | 0.74 | 0.32 | 0.06 | 0.79 | 0.40 | 0.96 | 0.24 | |
| P valueb# | 0.63 | 0.31 | 0.03 | 0.30 | 0.43 | 0.99 | 0.18 |
Data are expressed as the means ± SEM
a Adjusted for year of birth and sex
b Adjusted for year of birth, sex and BMI
* Variables were log-transformed before statistical analysis; numbers in the table were back-transformed
# p for trend
$ This group had too few subjects and no SEM was calculated
&Significant after Bonferroni correction (p < 0.0014 (0.05/36) was the corrected statistically significant level in association analysis between the individual SNP and quantitative traits in the control group)