Table 2.
α-bisabolol cytotoxicity in acute leukemia cells and in their normal counterparts (% mean values ± SD according to α-bisabolol concentration).
| μM α-bisabolol | 20 | 40 | 80 | 160 | IC50 | p | |
|---|---|---|---|---|---|---|---|
| Ph-B-ALL | 14 | 37 ± 36 | 55 ± 37 | 87 ± 12 | 100 | 33 ± 15 |
<0.05 ns |
| Ph+B-ALL | 14 | 2 ± 19 | 42 ± 28 | 81 ± 17 | 98 ± 2 | 46 ± 11 | |
| AML | 14 | 10 ± 9 | 32 ± 21 | 72 ± 11 | 96 ± 4 | 54 ± 8 | |
| cluster 1 | 8 | 72 ± 24 | 94 ± 6 | 99 ± 1 | 100 | 14 ± 5 |
<0.05 <0.05 |
| cluster 2 | 19 | 17 ± 9 | 44 ± 14 | 77 ± 15 | 97 ± 3 | 45 ± 7 | |
| cluster 3 | 15* | 3 ± 3 | 14 ± 8 | 73 ± 14 | 98 ± 2 | 65 ± 5 | |
| 17§ | 2 ± 3 | 14 ± 8 | 71 ± 16 | 97 ± 3 | 64 ± 5 | ||
| CD34+ | 5 | 1 ± 2 | 22 ± 19 | 72 ± 35 | 98 ± 1 | 62 ± 9 |
ns <0.05 |
| CD33+my | 5 | 2 ± 2 | 4 ± 3 | 40 ± 39 | 99 ± 1 | 95 ± 7 | |
*acute leukemia samples
§15 acute leukemias plus CD34+ and CD33+my samples