Table 2.
Host and viral baseline parameters in patients with and without treatment response
| SVR n = 29 |
non-SVR n = 21 |
Univariate p value |
|
|---|---|---|---|
| Age (mean) | 45.2 | 48.8 | 0.09a |
| Number of patients < 45 / > 45 yrs | 11 / 18 | 4 / 17 | 0.21b |
| Gender (m/f) | 17 / 12 | 13 / 8 | 1.0b |
| Baseline HCV RNA (mean log IU/mL) | 6.37 | 6.59 | 0.56a |
| Number with < 5.6 / > 5.6 log IU/mL | 8 / 21 | 0 / 21 | 0.01b |
| Genotype 1a/1b | 21 / 8 | 16 / 5 | 1.0b |
| Fibrosis (F0/F1/F2/F3/F4)c | 0 / 10 / 13 / 4 / 0 | 2 / 4 / 4 / 7 / 2 | 0.19d |
| Core aa 70 | 28 R / 1 Q | 15 R / 5 Q & 1 P | 0.03b |
| Core aa 91 | 21 C / 6 M / 2 L | 16 C / 3 M / 2 L | 0.82e |
| rs12979860 | 16 CC / 13 CT / 0 TT | 2 CC / 11 CT / 8 TT | 0.0001e |
a Mann-Whitney U test.
b Fisher's exact test.
c Fibrosis was scored according to Ludwig and Batts, and was available for 34 patients.
d Logistic regression.
e Chi square test.