Table 5.

The association between frequency of PROXIMAL depressive symptoms (Phases 5, 6, 7) and cognitive deficit^† at phase 7.

	Not Depressed	Depressed 1 time	Depressed 2 or 3 times
	N=3399 (79.6%)	N=535 (12.5%)	N=337 (7.9%)
		OR (95% CI)	OR (95% CI)
Memory
adjusted for age, sex, marital status & education	1	1.13 (0.87–1.48)	1.74 (1.30–2.34)*
+ diabetes, CHD, hypertension, stroke, & anti-depressant use	1	1.12 (0.86–1.47)	1.70 (1.26–2.29)*
AH4-I (reasoning)
adjusted for age, sex, marital status & education	1	1.30 (1.02–1.64)*	1.75 (1.33–2.30)*
+ diabetes, CHD, hypertension, stroke, & anti-depressant use	1	1.30 (1.03–1.66)*	1.76 (1.32–2.33)*
Mill Hill (vocabulary)
adjusted for age, sex, marital status & education	1	1.20 (0.95–1.52))	1.58 (1.20–2.09)*
+ diabetes, CHD, hypertension, stroke, & anti-depressant use	1	1.20 (0.95–1.52	1.57 (1.18–2.08)*
Phonemic fluency
adjusted for age, sex, marital status & education	1	1.09 (0.85–1.39)	1.51 (1.14–2.00)*
+ diabetes, CHD, hypertension, stroke, & anti-depressant use	1	1.08 (0.84–1.39)	1.48 (1.11–1.98)*
Semantic fluency
adjusted for age, sex, marital status & education	1	0.95 (0.73–1.24)	1.80 (1.36–2.39)*
+ diabetes, CHD, hypertension, stroke, & anti-depressant use	1	0.95 (0.73–1.24)	1.76 (1.32–2.36)*
MMSE
adjusted for age, sex, marital status & education	1	1.03 (0.77–1.37)	1.70 (1.25–2.31)*
+ diabetes, CHD, hypertension, stroke, & anti-depressant use	1	1.00 (0.75–1.34)	1.59 (1.16–2.18)*

^†Worst sex-specific quintile of cognitive function at Phase 7; covariates drawn from Phase 7.

^‡Not depressed at the 3 proximal measures of depressive symptoms.