Table 3.
Model parameter estimates for different fractional polynomial network meta-analysis models.
| Fixed effects model, first order fractional polynomial | Fixed effects model, second order fractional polynomial | Random effects model (d0), second order fractional polynomial | |||||
|---|---|---|---|---|---|---|---|
| Median of posterior distribution | 95% Credible Interval | Median of posterior distribution | 95% Credible Interval | Median of posterior distribution | 95% Credible Interval | ||
| p1 | power 1 | -2 | -2 | -2 | |||
| p2 | power 2 | 1 | 1 | ||||
| Pooled estimate for difference in β0 | |||||||
| d0AB | gefitinib vs. docetaxel | -0.003 | (-0.111; 0.112) | 0.158 | (-0.065; 0.409) | 0.144 | (-0.156; 0.411) |
| d0AC | BSC vs. docetaxel | 0.770 | (0.598; 0.939) | 1.674 | (1.108; 2.193) | 1.653 | (1.039; 2.167) |
| d0AD | pemetrexed vs. docetaxel | 0.020 | (-0.189; 0.243) | 0.141 | (-0.483; 0.744) | 0.142 | (-0.540; 0.761) |
| Pooled estimate for difference in β1 | |||||||
| d1AB | gefitinib vs. docetaxel | 0.634 | (-0.429; 1.726) | -0.003 | (-1.470; 1.362) | 0.070 | (-1.330; 1.542) |
| d1AC | BSC vs. docetaxel | -2.507 | (-4.281; -0.783) | -5.858 | (-8.503; -3.228) | -5.839 | (-8.265; -3.131) |
| d1AD | pemetrexed vs. docetaxel | -0.995 | (-3.344; 1.381) | -1.359 | (-4.604; 1.885) | -1.368 | (-4.511; 1.814) |
| Pooled estimate for difference in β2 | |||||||
| d2AB | gefitinib vs. docetaxel | -0.007 | (-0.016; 0.002) | -0.006 | (-0.015; 0.003) | ||
| d2AC | BSC vs. docetaxel | -0.053 | (-0.082; -0.023) | -0.052 | (-0.079; -0.023) | ||
| d2AD | pemetrexed vs. docetaxel | -0.005 | (-0.032; 0.023) | -0.005 | (-0.031; 0.022) | ||
| σd0 | Standard deviation of d0 ; heterogeneity in difference of β0 across comparisons | 0.060 | (0.002; 0.406) | ||||