Figure 7. PADK-mediated reductions of intraneuronal accumulation in the APP_SwInd mice.

Non-transgenic control (wt) and APP_SwInd mice were treated with 9 daily injections of PADK or vehicle. Brain sections were stained with the 6E10 antibody, and photomicrographs indicate PADK-mediated reductions of the intracellular labeling in hippocampal subfields and piriform cortex (A). Image analysis for densitometric quantification was conducted across view-fields of four different neuronal layers (B), and mean integrated optical densities were plotted (±SEM). Individual ANOVAs: P<0.0001; Tukey's post hoc tests compared to APP_SwInd+vehicle: **P<0.001. Size bar: 40 µm, CA1 and DG; 65 µm, piriform cortex. DG, dentate gyrus; sg, stratum granulosum; sp, stratum pyramidale.