Figure 6.
The mean percentage of DNA methylation at each CpG site of maternal and paternal IGF2 DMR2 clones are shown for liver, muscle and kidney and three development stages foetal, newborn and adult. Profiles were similar for both parental alleles and the three different tissue samples. For most of the CpG sites a moderate hypermethylation was found. A minor higher DNA methylation content was observed on the maternal allele in the foetal and newborn liver as compared to the paternal allele. The IGF2-exon9-612A>T SNP is located downstream of the 17th CpG site and not indicated.