Figure 1. Differential amounts of muscle miRNAs in the sera of healthy versus dystrophic children.

1. Box plots comparing microRNA levels in the sera of 7 healthy, 26 Duchenne (DMD), and 5 Becker (BMD) patients (patient information is listed in supplementary Table 1). All data were normalized for three spiked miRNAs (ath-miR-159a, cel-lin-2, and cel-lin-4). miR-1, miR-206, and miR-133 values are shown as copy number per ml of serum. Control miR-223 levels are also shown as fold change values. All values are shown in logarithmic scale. p-values are derived from the comparison of miRNA levels in DMD or BMD versus healthy patients.
2. ROC curves regarding diagnostic power to distinguish healthy from dystrophic cases. Area under the curve (AUC) values are also shown.