Figure 2.

Diagram showing the scores for health-related quality of life (HRQOL) on the 50-item Child Health Questionnaire (score range 0–100) in pediatric patients with tumor necrosis factor receptor–associated periodic syndrome (TRAPS) with structural mutations of the TNFRSF1A gene (solid diamonds) and pediatric patients with the R92Q mutation (shaded squares), in comparison with healthy children (open diamonds). HRQOL was assessed as the mean of the 2 summary scores for the physical domain (PhS) and the psychological domain (PsS) and the 15 subscales. Asterisks for each item indicate the P values for significant or nonsignificant (NS) differences in HRQOL between TRAPS patients/patients with R92Q as compared with healthy controls. ∗ = P < 0.05; ∗∗ = P < 0.01; ∗∗∗ = P < 0.001, by Mann-Whitney U test.