Fig 2.

Excerpt graphs from Camphausen et al. showing in vitro and in vivo radiosensitization of glioma cells by valproic acid treatment (28). (A) U251 and SF539 glioma cells were treated with valproic acid both before and following radiation. Clonogenic survival curves reveal an increase in radiosensitivity in valproic acid treated cells. (B) The effects of valproic acid and radiation on tumour growth delay. U251 glioma cells were implanted into the hind leg of mice and divided into four treatment groups: (1) control, (2) 4 Gy radiation, (3) valproic acid, (4) valproic acid and 4 Gy radiation. The combination treatment regimen showed the most significant tumour growth delay.