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. Author manuscript; available in PMC: 2012 Jun 1.
Published in final edited form as: Trends Biochem Sci. 2011 Apr 30;36(6):320–328. doi: 10.1016/j.tibs.2011.03.006

Figure 2.

Figure 2

Pathway Crosstalk. The Ras-MAPK and PI3K-mTORC1 pathways regulate each other via cross-inhibition (red) and cross-activation (green). Each pathway has a mechanism to negatively feed onto the other: ERK phosphorylation of GAB and AKT phosphorylation of Raf. Components of the Ras-ERK pathway (Ras, Raf, ERK, and RSK) also positively regulate the PI3K-mTORC1 pathway. TSC2 and mTORC1 are key integration points that receive many inputs from both the Ras-ERK and PI3K signaling. Positive regulation of the substrate protein is shown as an arrow. Negative regulation of the substrate protein is depicted as a blunt-ended line.