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. 2011 Jul;133(3):386–396. doi: 10.1111/j.1365-2567.2011.03449.x

Figure 2.

Figure 2

Mannose receptor (MR) participates in the induction of the increased arginase expression and activity, as well as transforming growth factor-β (TGF-β) and interleukin-10 (IL-10) production exerted by Fasciola hepatica excretory–secretory products (FhESP) on peritoneal macrophages (pMΦ). Arginase activity (a), Arginase I (Arg I) expression (b), as well as TGF-β and IL-10 production (c), were determined in pMΦ pre-incubated with mannan (1 mg/ml) or anti-MR for 30 min at 37° before being stimulated with FhESP (20 μg/ml) for 48 hr. Data are mean ± SEM of three independent experiments, analysed in triplicate. *P<0·05 respect to pMΦ in medium alone; #P<0·05 respect to pMΦ stimulated with FhESP.