Skip to main content
. 2011 Jul;133(3):386–396. doi: 10.1111/j.1365-2567.2011.03449.x

Figure 4.

Figure 4

Dectin-1 participates in the increased arginase expression and activity, as well as in the higher Transforming growth factor-β (TGF-β) and interleukin-10 (IL-10) production induced by Fasciola hepatica excretory–secretory products (FhESP) on peritoneal macrophages (pMΦ). Arginase activity (a), Arginase I (Arg I) expression by Western blot (b), as well as TGF-β and IL-10 levels (c) were determined in pMΦ pre-incubated with Laminarin (0·5 mg/ml), anti-Dectin-1 specific antibody (0·5 μg/ml), or Syk inhibitor (20 μm) for 30 min at 37° before being stimulated with FhESP (20 μg/ml) for 48 hr. Data are mean ± SEM of three independent experiments, analysed in triplicate. *P<0·05 respect to pMΦ in medium alone; #P<0·05 respect to pMΦ stimulated with FhESP.