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. Author manuscript; available in PMC: 2011 Jun 11.
Published in final edited form as: Antioxid Redox Signal. 2007 Nov;9(11):1911–1921. doi: 10.1089/ars.2007.1795

Figure 1.

Figure 1

Overview of mammalian one carbon metabolism. Four genetic mouse models involving disruptions of enzymes in this pathway have been highlighted in grey as has betaine-homocysteine methyltransferase, where transient enzyme deficiencies have been induced by treatment of mice with an inhibitor. Abbreviations: BHMT, betaine-homocysteine methyltransferase; CBS, cystathionine β-synthase; CGL, cystathionine γ-lyase; DHFR, dihydrofolate reductase; DMGD, dimethylglycine dehydrogenase; GNMT, glycine N-methyltransferase; MAT, methionine adenosyltransferase; MS, cobalamin-dependent methionine synthase; MSR, methionine synthase reductase; MTHFR, methylenetetrahydrofolate reductase; MTs, AdoMet-dependent methyltransferases; SAHH, S-adenosylhomocysteine hydrolase; SDH, sarcosine dehydrogenase; SHMT, serine hydroxylmethyltransferase; TS, thymidylate synthase.