Table 1.
Metabolite concentrations in plasma and liver tissue of mouse models for hyperhomocyst(e)inemia
| Mouse modela | Reference | Hcy (μM) | Met (μM) | AdoMet (nmol/g liver) | AdoHcy (nmol/g liver) | [AdoMet]: [AdoHcy] | 5-MethylTHF (% liver folates) |
|---|---|---|---|---|---|---|---|
| genotype/treatment | |||||||
| Mtrr | (13) | ||||||
| +/+ | 4.6±0.8 | 59.4±7.4 | 45.9±4.5 | 60.6±8.3 | 0.9±0.2 | 27±4 | |
| +/Gt | 5.5±1.8 | 48.9±10.5 | ND | ND | ND | ND | |
| Gt/Gt | 18.4±5.5 | 40.4±6.6 | 64.1±6.4 | 30.7±4.7 | 2.9±0.6 | 34±10 | |
| Mtr | (61) (9) |
||||||
| +/+ | 4.1 | 78 | 33.1±4.7 | 22.4±2.2 | 1.5±0.2 | ND | |
| +/− | 6.1 | 102 | 42.1±4.4 | 20.2±2.2 | 2.3±0.3 | ND | |
| −/− | NA | NA | NA | NA | NA | NA | |
| Mthfr | (4) | ||||||
| +/+ | 3.3±1.0 | ND | 27.7±0.3 | 13.8±0.3 | 2.0 | 23±12 | |
| +/− | 5.3±0.8 | ND | 36.3±0.7 | 36.3±0.5 | 1.0 | 13±6 | |
| −/− | 32.3±5.5 | ND | 19.0±0.7 | 55.4±0.9 | 0.3 | 0.9±1.3 | |
| Cbs | (68) (9) |
||||||
| +/+ | 6.1±0.8 | 22.8±1.6 | 42.9±8.8 | 27.4±2.9 | 1.7±0.2 | ND | |
| +/− | 13.5±3.2 | 30.6±2.5 | 41.9±3.1 | 45.7±5.1 | 1.0±0.1 | ND | |
| −/− | 203.6±65.3 | ND | ND | ND | ND | ND | |
| BHMT | (7) | ||||||
| −CBHcy | 2.3±0.2 | ND | 16.4±2.0 | 15.1±1.5 | 1.1 | ND | |
| +CBHcy | 18.5±1.0 | ND | 8.1±0.9 | 19.4±1.1 | 0.4 | ND |