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. Author manuscript; available in PMC: 2012 Feb 11.
Published in final edited form as: Biochem Biophys Res Commun. 2011 Jan 7;405(2):173–179. doi: 10.1016/j.bbrc.2011.01.002

Figure 1. Distribution of ALDH1A1 and ALDH1B1 in normal human tissues by IHC.

Figure 1

Positive staining (brown) displayed a diffuse cytoplasmic pattern for ALDH1A1 (A), but a cytoplasmic punctate pattern for ALDH1B1 (B). Hepatocytes were strongly stained for both proteins. In the colon, cells at the crypt bottom were positively stained with both ALDH1A1 and ALDH1B1 (arrows), whereas the immunopositivity of ALDH1A1 was also noted in partially differentiated cells at higher crypt levels (arrowheads). The bronchiole epithelium and Clara cells in the lung showed immunopositivity of ALDH1A1 and to a lesser extend of ALDH1B1. In the breast, IHC-signal of ALDH1A1 was barely notable and observed only in luminal epithelial cells (arrows); in contrast, the acinar and ductal lining columnar cells and the basal cells beneath them were all positively stained for ALDH1B1. In the ovary, the surface simple cuboidal cells (arrows) stained negatively for ALDH1A1, but quite intensely for ALDH1B1. Representative images are presented at two magnifications, with the squared field in the top panel (400×) enlarged in the bottom panel (1000×).