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. Author manuscript; available in PMC: 2011 Jun 11.
Published in final edited form as: Pain Pract. 2010 Mar 2;10(3):185–200. doi: 10.1111/j.1533-2500.2010.00358.x

Figure 2. TRPV1 protein topology.

Figure 2

TRPV1 is distinguished by six transmembrane spanning regions flanked by two intracellular domains (N) amino-terminal and (C) carboxyl-terminal. The N-terminal domain includes three ankyrin (A) repeat domains that may function in receptor modulation. A pore loop domain is predicted between the fifth and sixth transmembrane spanning region. It is proposed that at least four such subunits assemble to form a functional channel complex. Formation of hetermomeric channel complexes incorporating TRPV1 plus other TRPV1 splice variant and/or TRP – channel subunits have been proposed.