Table 3.
isolate | phenotype (trofile) | prediction from bulk-sequence, predicted as X4 at FPRa of: | MPS, proportion. predicted as X4b |
---|---|---|---|
1 | X4 | 2.5% | 85.3% |
2 | X4 | 5% | 87.0% |
3 | X4 | 10% | 14.2% |
4 | X4 | 15% | 5.4% |
5 | X4 | 15% | 48.0% |
6 | X4 | ---c | 68.5% |
7 | X4 | --- | 1.0% |
8 | R5 | 10% | 1.4% |
9 | R5 | --- | 3.4% |
10 | R5 | --- | 0.3% |
11 | R5 | --- | 0.5% |
12 | R5 | --- | 1.6% |
13 | R5 | --- | 1.8% |
14 | R5 | --- | 2.4% |
Tropism results from different approaches used: phenotype (trofile), coreceptor usage prediction from bulk-genotype, and coreceptor usage prediction from massively parallel sequencing.
FPR: false-positive-rate of geno2pheno.
athe displayed value is the highest cutoff at which an isolate would have been predicted as X4
bdefault geno2pheno[coreceptor]-cutoff of 10% FPR used
c '---' if predicted FPR, was above the highest cutoff tested (20%)