Table 1.
Gene Set Enrichment Analysis of representative gene sets identified as significantly enriched after 1,25(OH)2D3 treatment in the presence of androgen in LNCaP cells.
| Biological Process | Testosterone | 1,25(OH)2D3 | T & D | |||
|---|---|---|---|---|---|---|
| Median Change | p-value | Median Change | p-value | Median Change | p-value | |
| Mitosis | -1.54 | 3.51E-10 | -1.98 | 3.63E-07 | -3.63 | 1.27E-15 |
| Microtubule-based movement | -1.62 | 2.54E-05 | -2.11 | 1.17E-04 | -4.19 | 5.78E-07 |
| Chromosome segregation | -1.61 | 1.11E-03 | -1.99 | 2.13E-03 | -3.44 | 1.12E-04 |
| Anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process | -1.47 | 5.90E-03 | n/a | n/a | -3.63 | 2.10E-03 |
| DNA repair | n/a | n/a | -1.77 | 1.08E-02 | -2.55 | 2.24E-03 |
| DNA recombination | n/a | n/a | -2.02 | 4.30E-02 | -3.42 | 1.41E-02 |
| Phosphoinositide-mediated signaling | n/a | n/a | -1.73 | 4.97E-02 | -2.40 | 1.60E-02 |
| Elevation of cytosolic calcium ion concentration | n/a | n/a | 2.02 | 1.76E-02 | 3.43 | 2.95E-02 |
(False Discovery Rate <5%)