Table 2.

FIQ total scores and VAS subscales throughout the study (mean ± sd) (ES: effect sizes)

	baseline	week 6	week 12	week 18	week 24	P
Total scores	78.6 ± 11.5	72.2 ± 14.4	68.6 ± 16.6***	66.5 ± 18.1***	65.2 ± 18.5***	<0.0001
ES		0.56	0.88	1.06	1.17
Work	8.19 ± 1.4	7.44 ± 1.9*	7.21 ± 2.1**	7.17 ± 2.1**	6.77 ± 2.4***	<0.0001
ES		0.54	0.71	0.73	1.02
Pain	8.46 ± 1.4	7.92 ± 1.3	7.51 ± 1.8**	7.33 ± 1.09**	7.05 ± 2.3***	<0.0001
ES		0.38	0.70	0.81	1.04
Fatigue	8.72 ± 1.2	8.02 ± 1.9	7.92 ± 1.6**	7.97 ± 1.7**	7.55 ± 2.3***	<0.0001
ES		0.58	0.67	0.62	1.00
Morning tiredness	8.85 ± 1.2	7.64 ± 2.4	7.63 ± 2.4**	7.51 ± 2.3**	7.17 ± 2.4***	<0.0001
ES		1.00	1.02	1.12	1.39
Stiffness	8.44 ± 1.7	7.55 ± 2.5**	7.26 ± 2.6**	7.15 ± 2.6**	7.06 ± 2.5***	= 0.0006
ES		0.52	0.72	0.81	0.83
Anxiety	8.31 ± 1.7	7.47 ± 2.7	6.99 ± 2.5**	7.03 ± 2.4**	6.96 ± 2.4**	= 0.0006
ES		0.49	0.78	0.75	0.78
Depression	7.90 ± 2.8	6.88 ± 2.9	7.01 ± 3.1	6.97 ± 2.7	6.85 ± 3.0	= 0.0754
ES		0.36	0.32	0.33	0.38

*: p < 0.5, **: p < 0.01 and ***: p < 0.001 in relation to baseline (Tukey's post-test). Bold: large effect sizes.