Table 2.
Pharmacokinetic parameters of rh-HGF
| parameters | Estimate values | 95% confidence interval | |
|---|---|---|---|
| Day 1 | |||
| Cmax (ng/mL) | 18.8 | 13.0 | 24.7 |
| AUC0-300 (ng/mL*min) | 1485.6 | 991.3 | 1979.8 |
| AUC0-∞ (ng/mL*min) | 1994.0 | 1214.6 | 2773.3 |
| T1/2 (min) | 756.2 | 526.8 | 985.7 |
| CL (mL/m2/min) | 0.000361 | 0.000160 | 0.000561 |
| Vdss (mL/m2) | 0.125 | 0.063 | 0.186 |
| Day 5 | |||
| Cmax (ng/mL) | 21.3 | 12.8 | 29.9 |
| AUC0-300 (ng/mL*min) | 1727.2 | 1099.7 | 2354.7 |
| AUC0-∞ (ng/mL*min) | 2493.8 | 1647.0 | 3340.5 |
| T1/2 (min) | 843.6 | 540.5 | 1146.6 |
| CL (mL/m2/min) | 0.000277 | 0.000138 | 0.000416 |
| Vdss (mL/m2) | 0.106 | 0.059 | 0.153 |
| Day 11 | |||
| Cmax (ng/mL) | 22.3 | 11.4 | 33.1 |
| AUC0-300 (ng/mL*min) | 1965.5 | 801.6 | 3129.5 |
| AUC0-∞ (ng/mL*min) | 3126.4 | 1355.2 | 4897.5 |
| T1/2 (min) | 633.3 | 318.0 | 948.6 |
| CL (mL/m2/min) | 0.000230 | 0.000095 | 0.000365 |
| Vdss (mL/m2) | 0.088 | 0.031 | 0.146 |