Figure 2.
Effect of resveratrol on melanoma cell retention in the hepatic microvasculature of intrasplenically-injected B16M. RVL was administrated via intragastric tube (1 mg/kg/day) during 5 days prior to 3 × 105 B16M-Luc cell intrasplenic injection. After 18 hours livers were removed and light production was measured as described in Methods. Light emission values were expressed as relative light units and the number of arrested B16M-Luc cells was calculated on the basis of a standard curve relating specific relative light units to B16M-Luc cell number. Data represent average values ± SD of two separate experiments. *Differences were statistically significant (P < 0.01) to respect to vehicle-treated mice, by Student's two tailed, unpaired t test.