Table 2.
Sensitivity, specificity & ROC* for saliva derived seroprevalence to P. falciparum merozoite surface antigens
Sensitivity (95% CI) | Specificity (95% CI) | ROC (95% CI) | |
---|---|---|---|
AMA-1 | |||
Tanzania Oracol | 76.7 (54.9-90.6) | 100 (87.7-100) | 0.88 (0.8-0.96) |
Tanzania Orasure | 64 (42.5-82) | 92.9 (76.5-99.1) | 0.78 (0.68-0.89) |
The Gambia | 68 (56-78.8) | 91.2(85-95.6) | 0.80(0.74-0.86) |
MSP-119 | |||
Oracol | 46.7 (21.3-73.4) | 97.4 (86.2-99.9) | 0.72 (0.58-0.85) |
Orasure | 66.7 (38.4-88.2) | 90.0(75.2-97.1) | 0.78 (0.64-0.91) |
The Gambia | 53 (40.1-66.5) | 94.2(89-87.5) | 0.74(0.67-0.81) |
* ROC = receiver operating characteristic curve; the average of sensitivity and specificity
Fingerprick derived plasma antibody prevalence was the gold standard for sensitivity and specificity analysis.