Table 5.
Prevalence of dhps gene mutations at enrolment and at day of failure in children included in the in vivo study
| DHPS | |||||
|---|---|---|---|---|---|
| Pre-treatment | |||||
| 436/437 SA | 436/437 SG | 436/437 AA | 436/437 AG | N = 29 | % |
| 0 | 1 | 0 | 0 | 11 | 38 |
| 1 | 0 | 0 | 0 | 1 | 3 |
| 1 | 1 | 0 | 0 | 1 | 3 |
| 0 | 1 | 0 | 1 | 2 | 7 |
| 0 | 0 | 1 | 0 | 2 | 7 |
| 0 | 1 | 1 | 0 | 7 | 24 |
| 1 | 0 | 1 | 0 | 1 | 3 |
| 0 | 1 | 1 | 1 | 4 | 14 |
| Post-treatment | |||||
| 436/437 SA | 436/437 SG | 436/437 AA | 436/437 AG | N = 26 | % |
| 0 | 0 | 0 | 0 | 11 | 42 |
| 0 | 1 | 0 | 0 | 10 | 38 |
| 1 | 1 | 0 | 0 | 1 | 4 |
| 0 | 0 | 0 | 1 | 1 | 4 |
| 0 | 0 | 1 | 0 | 2 | 8 |
| 0 | 1 | 1 | 0 | 1 | 4 |
SA: sensitive, wild-type; SG: single mutant 437G; AA: single mutant 436A; double mutant 436A + 437G