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. Author manuscript; available in PMC: 2012 Jul 20.
Published in final edited form as: Virology. 2011 May 14;416(1-2):1–8. doi: 10.1016/j.virol.2011.04.012

Figure 7. HeLa-Tax cells display broken DNA-containing micronuclei and nucleoplasmic bridges.

Figure 7

HeLa-Tax cells were stained for DNA end labelling (red) and counterstained with DAPI (blue). The bright field image is overlaid in panels A and B. A. HeLa-Tax cells show multiple micronuclei (round pink structures), sometimes 3-4 per cell that stain positive for DNA ends. B. A nucleoplasmic bridge is shown stretching between the nuclei of two daughter cells after cell division. The extracellular part of the bridge stains positive for free DNA ends. C. DAPI signal is shown for the image in panel B. The arrow indicates a broken chromosome segment from the nucleoplasmic bridge. All images were taken at 40× magnification.