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. Author manuscript; available in PMC: 2012 Jun 1.
Published in final edited form as: Mol Cancer Ther. 2011 Apr 6;10(6):949–959. doi: 10.1158/1535-7163.MCT-10-0904

Figure 5. Inactivation of GSK3β with Lithium Chloride decreases Linifanib induced apoptotic effects.

Figure 5

Ba/F3 hFLT3 ITD mutant cell lines were treated with 10nM Linifanib alone or in combination with GSK3β inhibitor Lithium Chloride at a concentration of 10mM for 24 hours and 48 hours. 1×106 cells were stained with AnnexinV/Propidium Iodide and analyzed by flow cytometry. From multiple experiments, the mean ± standard deviation of percent Annexin-V/PI positive cells were analyzed with a one-way ANOVA followed by Tukey (post-hoc) test. * Significant differences between combinations were observed (P < 0.05)