Figure 3.

Schematic representation of prereplication machinery recruitment. Figure 3 shows that Cdc6 and ORC ATPase activities are important for the release of these molecules from the complex. Asterisks show the steps where ORC ATPase activity (purple ∗) or Cdc6 ATPase activity (orange ∗) is important for the prevention of the assembly of the prereplication machinery at nonspecific replication origins.