Figure 5. Schematic model depicting a role of RGS16 in regulated cAMP signalling at dawn in the dorsomedial cells.

Through allowing cAMP synthesis at dawn, RGS16 regulates Per1 expression in the dorsomedial phase-leading cells. B, BMAL1; C, CLOCK; CRE, cAMP responsive element; CREB, CRE-binding protein; D, DBP; P, phosphate; ERK, extracellular signal-regulated kinase; PKA, cAMP-dependent protein kinase.