Figure 6. Effects of deletion of the regulatory insertion (ΔRI) on WT- and ΔF508-CFTR channels.

A, representative current traces of ΔRI-CFTR locked open by 1 mm ATP and 2 mm PP_i (left) and ATP/P-ATP ligand exchange (right). B, representative current traces of ΔRI/ΔF508-CFTR locked open by 1 mm ATP and 2 mm PP_i (left) and ATP/P-ATP ligand exchange (right). The current decay upon ligand wash-out was fitted with a single exponential function, while the current rising phase was fitted with a double exponential function.