Table 1.
In neuropathic animals, a larger proportion of DHNs generate plateau potentials
Mechanical threshold | Plateau neurones in superficial laminae | Plateau neurones in deep laminae | ||||
---|---|---|---|---|---|---|
Force (g) | % | n | % | n | % | |
Control | 67.1 ± 3.9 | 100 ± 6.6† | 0/7 | 0 | 7/25 | 28.0* |
SNL | 31.9 ± 1.8 | 47.6 ± 2.6† | 0/4 | 0 | 5/6 | 83.3* |
†P < 0.0001 | *P = 0.02 |
P = 0.02 versus naive rats.
The expression of plateaus appears specific to DHNs in deep laminae (deeper than 350 μm of the spinal cord surface). Recordings were obtained from allodynic rats presenting a clear decrease in the threshold force required to trigger withdrawal of the paw
P < 0.0001.