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. 2011 Mar 21;589(Pt 11):2857–2870. doi: 10.1113/jphysiol.2010.204594

Figure 5. Selective impairment of low threshold mechanosensitivity induced by HFF diet.

Figure 5

Single units were discriminated from the whole nerve recording using computer software and classified into low and high threshold units. A, pressure–response relationship of low threshold units. Low threshold afferent activity was significantly attenuated in preparations from HFF mice (n = 27 units) compared to preparations from LFF mice (n = 19 units, P < 0.0001, 2-way ANOVA and Bonferroni post hoc test). B, pressure–response relationship of high threshold units. High threshold afferent activity was not altered in preparations from HFF mice (n = 15 units) compared to preparations from LFF mice (n = 14 units). C, the proportion of low threshold and high threshold afferents was similar between the two groups (P > 0.05, Fisher's exact test).